I have been using FTP Voyager since 1999 or so. It is an amazing piece of software ; the synchronized mode by itself is absolutely a killer feature : the distant server window follows your moves between local folders. For web developers this totally out-perform solutions used in GoLive and the like.
The main lacking feature is scripting.
It is impossible, for example, to efficiently download periodically web servers log files without erasing previous logs, since there is no way to automate renaming of downloaded files, for example.
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